CYP2D6 EXPRESSION IS CUMULATIVELY UP REGULATED IN MULTIDRUG TREATED HEPATOMA CELLS: A PREDECTIVE PHARMACOGENETICS IN VITRO MODEL
نویسندگان
چکیده
منابع مشابه
Mcl-1 Is Up Regulated by Prenylated Coumarin, Umbelliprenin in Jurkat Cells
Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy in the western world and exists as subtypes with very different clinical courses. Myeloid cell leukemia 1 (Mcl-1) is one member of Bcl-2 family proteins that has been shown to be expressed in various tissues and malignant cells, including CLL, where its expression is significantly associated with a failure to achieve compl...
متن کاملMcl-1 Is Up Regulated by Prenylated Coumarin, Umbelliprenin in Jurkat Cells
Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy in the western world and exists as subtypes with very different clinical courses. Myeloid cell leukemia 1 (Mcl-1) is one member of Bcl-2 family proteins that has been shown to be expressed in various tissues and malignant cells, including CLL, where its expression is significantly associated with a failure to achieve compl...
متن کاملmcl-1 is up regulated by prenylated coumarin, umbelliprenin in jurkat cells
chronic lymphocytic leukaemia (cll) is the most common b-cell malignancy in the western world and exists as subtypes with very different clinical courses. myeloid cell leukemia 1 (mcl-1) is one member of bcl-2 family proteins that has been shown to be expressed in various tissues and malignant cells, including cll, where its expression is significantly associated with a failure to achieve compl...
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In vitro human studies show that the metabolism of most amphetamine-like psychostimulants is regulated by the polymorphic cytochrome P450 isozyme CYP2D6. Two compounds, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA), were selected as archetypes to discuss the translation and clinical significance of in vitro to in vivo findings. Both compounds were chosen based on their differenti...
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The interplay between inflammation, cervical cancer and HIV acquisition in women is poorly understood. We have previously shown that seminal plasma (SP) can promote cervical tumour cell growth in vitro and in vivo via the activation of potent inflammatory pathways. In this study, we investigated whether SP could regulate expression of chemokine receptors with known roles in HIV infection, in th...
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ژورنال
عنوان ژورنال: The Egyptian Journal of Biochemistry and Molecular Biology
سال: 2020
ISSN: 2090-2603
DOI: 10.21608/ejb.2020.136526